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作者：非文人 在 罕见奇谈 发贴, 来自 http://www.hjclub.org
TI: An African HIV-1 sequence from 1959 and implications for the origin of the epidemic.
AU: Zhu,-T; Korber,-B-T; Nahmias,-A-J; Hooper,-E; Sharp,-P-M; Ho,-D-D
SO: Nature. 1998 Feb 5; 391(6667): 594-7.
JN: Nature-;
IS: 0028-0836
LA: English
MA: There is considerable genetic diversity among viruses of different subtypes (designated A to J) in the major group of human immunodeficiency virus type 1 (HIV-1), the form of HIV that is dominant in the global epidemic. If available, HIV-1 sequences pre-dating the recognition of AIDS could be crucial in defining the time of origin and the subsequent evolution of these viruses in humans. The oldest known case of HIV-1 infection was reported to be that of a sailor from Manchester who died of an AIDS-like illness in 1959; however, the authenticity of this case has not been confirmed. Genetic analysis of sequences from clinical materials obtained from 1971 to 1976 from members of a Norwegian family infected earlier than 1971 showed that they carried viruses of the HIV-1 outlier group, a variant form that is mainly restricted to West Africa. Here we report the amplification and characterization of viral sequences from a 1959 African plasma sample that was previously found to be HIV-1 seropositive. Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV-1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959.
RO: National-Library-of-Medicine
HIV's origins traced to 1930s.
AU: Stephenson,-J
SO: JAMA. 2000 Mar 8; 283(10): 1279.
作者：非文人 在 罕见奇谈 发贴, 来自 http://www.hjclub.org |
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美政府曾斥巨资制造艾滋病和梅毒病毒 
