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主题: 敬请芦老和其他专业人士评点Cell上武汉病毒溯源的最新文章
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作者 敬请芦老和其他专业人士评点Cell上武汉病毒溯源的最新文章   
polarbear





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文章标题: 敬请芦老和其他专业人士评点Cell上武汉病毒溯源的最新文章 (365 reads)      时间: 2021-8-25 周三, 上午6:48

作者:polarbear驴鸣镇 发贴, 来自 http://www.hjclub.org

从结论看,这篇Critical Review文章基本上支持人畜传递说,虽然没有完全排除实验室泄露,但认为highly unlikely. 认为无证据支持早期病例与武毒所有关。与世卫之前的结论似乎没有什么差异。特别值得一提的是,与老芦质疑不同,该文章中认为这个病毒中的弗林酶切位点并无特别。

对此顶级刊物上最新文章之结论,请内行评点。

There is currently no evidence that SARS-CoV-2 has a laboratory origin. There is no evidence that any early cases had any connection to the WIV, in contrast to the clear epidemiological links to animal markets in Wuhan, nor evidence that the WIV possessed or worked on a progenitor of SARS-CoV-2 prior to the pandemic. The suspicion that SARS-CoV-2 might have a laboratory origin stems from the coincidence that it was first detected in a city that houses a major virological laboratory that studies coronaviruses. Wuhan is the largest city in central China with multiple animal markets and is a major hub for travel and commerce, well connected to other areas both within China and internationally. The link to Wuhan therefore more likely reflects the fact that pathogens often require heavily populated areas to become established (Pekar et al., 2021).

We contend that although the animal reservoir for SARS-CoV-2 has not been identified and the key species may not have been tested, in contrast to other scenarios there is substantial body of scientific evidence supporting a zoonotic origin. While the possibility of a laboratory accident cannot be entirely dismissed, and may be near impossible to falsify, this conduit for emergence is highly unlikely relative to the numerous and repeated human-animal contacts that occur routinely in the wildlife trade. Failure to comprehensively investigate the zoonotic origin through collaborative and carefully coordinated studies would leave the world vulnerable to future pandemics arising from the same human activities that have repeatedly put us on a collision course with novel viruses.


文章链接:

https://www.cell.com/cell/pdf/S0092-8674(21)00991-0.pdf

https://www.sciencedirect.com/science/article/pii/S0092867421009910

作者:polarbear驴鸣镇 发贴, 来自 http://www.hjclub.org
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